Pharmaceuticals & Biotechnology

Control the process. Find the cure.

At Linde, we provide critical gases and cryogens that sustain daily operations for our pharmaceutical and biotechnology customers. From research and development through scale-up and into full production, we have the gases you need, the way you need them. And Linde’s experience goes well beyond gas supply. Our advanced application expertise in gas-liquid mixing and temperature control engineering can help you achieve the process reproducibility, drug uniformity, product quality and cost savings you need to make the world a healthier place. So whether you’re tasked with drug discovery, process development, manufacturing, quality control, cell preservation, or any other facet of the industry, Linde’s broad gas portfolio (GMP and non-GMP), application innovation and supply distribution will help control the process, so you can focus on finding the cure.

Related Gases

Nitrogen

Gaseous nitrogen is commonly used for blanketing — protecting a process from moisture intrusion, oxidation, degradation and contamination. Additional uses include purging, pressure transferring, mixing and capturing air emissions. Cryogenic liquid nitrogen is used to control the temperature in reactor cooling applications and to preserve biological samples.

Oxygen

Critical for cell growth applications, oxygen is used in fermenters and bioreactors.

Carbon Dioxide

Carbon dioxide is used throughout the pharmaceutical market. As a gas, it is used in bench top incubators. In manufacturing, it is used in super critical fluid chromatography. And in wastewater treatment, it is used for self-buffered pH control.

Dry Ice

At temperatures of -109°F (-79°C) and below, dry ice provides the cooling capacity needed to transport temperature sensitive products.

Applications

Linde’s advances in liquid-nitrogen-based lyophilization technology have provided customers with greater operational flexibility, improved reliability and fewer maintenance demands. Our patented NCOOL™ heat exchanger has a refrigeration efficiency of > 95% and uses significantly less nitrogen than alternative cryogenic refrigeration systems. With high turn down capability, a compact footprint, and environmentally friendly operation, Linde’s NCOOL technology is ideal for today’s demanding lyophilization requirements.

Using direct oxygen injection and proprietary mixing technology, Linde can help overcome dissolved oxygen limitations and expand the productivity of aerobic microbial fermentation by up to 65%.

Linde’s cryogenic VOC (Volatile Organic Compounds) Recovery systems allow customers to comply with stringent emission regulations. We’ll work with you to fully understand your process, company-specific environmental initiatives, and regulatory restrictions. In turn, we’ll help you develop a comprehensive VOC recovery plan to meet your needs and your budget.

By inducing simultaneous nucleation of all the vials inside the freeze dryer chamber, our ControLyo™ technology can deliver improved product uniformity, quality and yield, while reducing cycle times by up to 40%.
Our non-freezing direct and indirect cooling equipment provides the rapid cooling and precise temperature control required for reaction and process optimization. By harnessing the cooling power of cryogenic nitrogen, our highly efficient systems (> 95%) eliminate the need for complex, multi-stage mechanical refrigeration. Customers have experienced reduced operating costs, less maintenance requirements and increased peace of mind.

Services

We do more than just provide industrial gases, application expertise and products to the pharmaceutical and biotechnology industry. We’ll help you to optimize every step of your process. From consultation to implementation and use, we offer a range of services that help you monitor and manage your gas supply so you can focus on finding the cure.

View our services portfolio

Products

Cryogenic Storage

At Linde, we offer a wide range of cryogenic storage equipment, including cryogenic freezers, controlled rate freezers and refrigeration back-up, critical for maintaining and handling biological materials.

Repository Equipment & Services

Linde has a complete repository offering including cryogenic storage freezers, cryoshippers, controlled rate freezers and O2 monitors. We also design and build CO2 back up systems for -80C° freezers, changeover panels, and a variety of gas handling equipment. As a fully integrated supplier, Linde provides cryogenic liquid nitrogen in dewars, microbulk and bulk tanks.